Dual specificity protein kinase clk2

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August undefined, 2024

WebIn biochemistry, a dual-specificity kinase ( EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase . MEKs, involved in MAP pathways, are … WebThe cdc2-like kinases (CLKs) are an evolutionarily conserved group of dual specificity kinases belonging to the CMGC (cyclin-dependent kinases (CDKs), mitogen-activated …

CLK2 CDC like kinase 2 [Homo sapiens (human)] - Gene

This gene encodes a member of the CLK family of dual specificity protein kinases. CLK family members have shown to interact with, and phosphorylate, serine/arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle progression, apoptosis, and telomere length regulation. WebHere, we show that Cdc2-like kinase 2 (Clk2) is an insulin-regulated suppressor of hepatic gluconeogenesis and glucose output. Clk2 protein levels and kinase activity are induced as part of the hepatic refeeding response by the insulin/Akt pathway. Clk2 directly phosphorylates the SR domain on PGC-1alpha, resulting in repression of ... herpes typ 2 pferd

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WebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 3, mRNA. (from RefSeq NM_001294339) RefSeq Summary (NM_001294338): This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of … WebDual specificity mitogen-activated protein kinase kinase 2: 1.337e-07: 0.32: CLK4_HUMAN: CLK4: Dual specificity protein kinase CLK4: 1.553e-07: 0.39: E3UJZ5_SPOLI: Ecdysone receptor: 1.59e-07: 0.29: CCNE1_HUMAN: CCNE1: G1/S-specific cyclin-E1: 1.68e-07: 0.45: DCLK1_HUMAN: DCLK1: Serine/threonine-protein … WebDec 15, 1999 · Abstract. CLK3, a member of the LAMMER family of dual-specificity protein kinases, is abundantly expressed in the reproductive system of male mice. Specifically, high levels of CLK3 protein expression are found in mature spermatozoa in the testis and epididymis. The majority of the CLK3 protein in the testis is a full-length … maxwell monachino

B1AVT0 - UniProt

WebFeb 5, 2024 · Go to Variation Viewer for CLK2 variants; Summary. This gene encodes a dual specificity protein kinase that phosphorylates serine/threonine and tyrosine-containing substrates. Activity of this protein regulates serine- and arginine-rich (SR) proteins of the spliceosomal complex, thereby influencing alternative transcript splicing. WebOct 2, 2024 · KLIFS — Kinase–Ligand Interaction Fingerprints and Structures — is a structural kinase database focusing on how kinase inhibitors interact with their targets. The aim of KLIFS is to support (structure-based) kinase research through the systematic collection, annotation, and processing of kinase structures. maxwell mortgage loginWebQuery Target Key Target Name Description P-Value MaxTC; compound_1 . PARP1_RAT: Parp1: Poly [ADP-ribose] polymerase 1: 5.09e-154 maxwell morelly law

"WebJun 15, 1998 · The prototype, murine Clk1 (mClk1), is a nuclear dual-specificity kinase that can interact with, and cause the nuclear redistribution of, SR proteins. In this study, we demonstrate that the human Clk2 and Clk3 (hClk2 and 3) are also found within the nucleus and display dual-specificity kinase activity. " - Dual specificity protein kinase clk2

Dual specificity protein kinase clk2

http://sea.docking.org/jobs/search_e5f5f9bf-3e76-4690-a2ef-acd8a42d053f This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. 1. Name1 2. SynonymsLong 3. See alsosequence in UniParc or sequence clusters in UniRef See more

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WebIn biochemistry, a dual-specificity kinase ( EC 2.7.12.1) is a kinase that can act as both tyrosine kinase and serine/threonine kinase . MEKs, involved in MAP pathways, are principal examples of dual-specificity kinases. Other common examples include: The systematic name of this enzyme class is ATP:protein phosphotransferase (Ser/Thr- and … WebApr 12, 2024 · The compound CC-671, an inhibitor of both CLK2 and the dual-specificity protein kinase TTK, blocked the growth of two cell lines and a patient-derived TNBC …

Web23.2.1.2 MEK1. The dual specificity kinase MEK1 controls Golgi disassembly by activating several regulatory kinases (Fig. 23.1). MEK1 is a central player of the MAP kinase signal … WebDescription: Homo sapiens CDC like kinase 2 (CLK2), transcript variant 2, mRNA. (from RefSeq NM_003993) RefSeq Summary (NM_003993): This gene encodes a dual …

WebCLKs (Cdc2-like kinase) are dual specificity protein kinases which are involved in gene splicing regulation. The CLK family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are useful targets for studying diseases attributed to gene mis-splicing events. Products. Background. Literature (1) Gene Data. CLK (Cdc2-like Kinase) Inhibitors; WebHuman Dual specificity protein kinase CLK2 contains a number of potential phosphorylation sites (SwissProt) which may explain the banding pattern at a higher molecular weight than predicted (64 kDa). Protocols. Western blot protocols. Immunocytochemistry & immunofluorescence protocols.

WebCDC-like kinase 2 nucleus, protein serine/threonine kinase activity, nucleotide binding, ATP binding, protein phosphorylation, protein binding, nucleolus, response to retinoic acid, nuclear speck, protein tyrosine kinase activity, response to ionizing radiation, negative regulation of gluconeogenesis, peptidyl-tyrosine phosphorylation, protein …

WebThe dual specificity kinase MEK1 controls Golgi disassembly by activating several regulatory kinases ( Fig. 23.1). MEK1 is a central player of the MAP kinase signal … maxwell mohr methodWebNM_001294339.2 → NP_001281268.1 dual specificity protein kinase CLK2 isoform 3. See identical proteins and their annotated locations for NP_001281268.1. Status: … herpes type 1 icd 10 codeWebJun 15, 1998 · The prototype, murine Clk1 (mClk1), is a nuclear dual-specificity kinase that can interact with, and cause the nuclear redistribution of, SR proteins. In this study, … maxwell mortgage employee reviewshttp://sea.docking.org/jobs/search_462fe35f-6251-418d-af8e-e6a4a6e03434 maxwell morgan pcWebSep 15, 2000 · CLK1 was one of the first identified dual specificity kinases and is the founding member of the ‘LAMMER’ family of kinases. We have established the substrate site specificity of CLK1. We report here that truncation of the N terminus of CLK1 resulted in a dramatic increase in CLK1 enzymatic activity, indicating that the N terminus acts as a … herpes type 1 and 2 blood testhttp://sea.docking.org/jobs/search_dd920cdf-bc2e-44c7-9fbd-8f637cdbcca7 maxwell montes on venus is a huge:WebApr 7, 2024 · The CLKs (Cdc2-like kinases) belong to the dual-specificity protein kinase family and play crucial roles in regulating transcript splicing via the phosphorylation of SR proteins (SRSF1–12 ... maxwell mortgage loans