Cisplatin-induced apoptosis

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August undefined, 2024

WebNov 3, 2024 · Purpose The nephrotoxicity caused by cisplatin severely limits the application and affects related platinum-based therapeutics. Neferine is a dibenzylisoquinoline alkaloid extracted from a Chinese … WebSilencing STING by siRNA rescued HaCaT cells from UVB or cisplatin-induced apoptosis. NF-κB, one of the major downstream components of STING pathway, which usually regulates the classical STING apoptotic pathway, was translocated to nucleus in the HaCaT cells irradiated with UVB. This translocation was attenuated by STING silencing.

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WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the … easy circle drawings

Neferine mitigates cisplatin-induced acute kidney injury …

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer … WebThe role of intra- and extracellular pH in apoptosis induction was investigated. Activation of caspase-3 and DNA ladder formation were used to monitor the apoptotic response. … WebJan 18, 2016 · Cisplatin induces apoptosis in renal tubular cells Previous studies have suggested that cisplatin might induce apoptosis in renal tubular epithelial cells 8. In our study, NRK-52E cells... easy cioppino seafood stew

Cisplatin-induced apoptosis in BUMPT cells. (A) BUMPT …

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WebSep 1, 2024 · Cisplatin is globally used for the treatment of human malignancies. Despite its efficacy, cisplatin use is associated with severe side effects, such as bone marrow suppression, peripheral neuropathy, ototoxicity, anaphylaxis, and nephrotoxicity (cisplatin-induced nephrotoxicity; CIN). WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis … easy city card wienWebCisplatin (cis-diamminedichloroplatinum; CDDP) 1 is a potent inducer of growth arrest and/or apoptosis in most cell types and is among the most effective and widely used chemotherapeutic agents employed for … cupon offer for xeomin

"WebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. ... We did not mean that these differences will result in differences in the extension of apoptosis induced by ABs because we knew from our previous work published in Biochimica et Biophysica … " - Cisplatin-induced apoptosis

Cisplatin-induced apoptosis

WebDec 12, 2024 · Cisplatin is one of the most generally used and highly effective chemotherapy drugs for the treatment of various types of human cancer, such as testicular, ovarian, head and neck, bladder, bone,... WebNov 3, 2024 · Apoptosis is known as one of the major mechanisms of cisplatin-induced cell death in renal tubular which had been further confirmed in some studies [ 5, 6 ]. Some research data have also demonstrated that autophagy induction is an immediate response of renal tubular epithelial cell exposure to cisplatin [ 7, 8 ].

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WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebOct 15, 2001 · cis-platinum(II) (cis-diammine dichloroplatinum; cisplatin) is a potent antitumor compound that is widely used for the treatment of many malignancies. An important side-effect of cisplatin is nephrotoxicity, which results from injury to renal tubular epithelial cells and can be manifested as either …

WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within 24–48 hr requires cisplatin concentrations that are … WebCisplatin-induced apoptosis in BUMPT cells. (A) BUMPT cells were untreated or treated with 40 μ mol/L cisplatin for 20 h. Cell morphology was recorded by phase- contrast microscopy (10 × ). (B)...

WebJan 17, 2024 · Cisplatin is a well-known chemotherapeutic drug. It is one of the most effective anticancer agents and is widely used for the treatment of several types of tumors. However, side effects in normal tissues and organs, such as nephrotoxicity that induces apoptosis in epithelial cells in the kidney, limit the use of cisplatin. WebMay 16, 2024 · Apoptosis level was detected by caspase 3/7 activity and DNA fragmentation. Results: The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy.

WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in …

WebVarious recent studies have investigated (GLP-1R) role in cardiovascular diseases due to antiapoptotic and antioxidant effects. The current study aimed to investigate the curative … cupon off road beltsWebRenal tubular epithelial cell apoptosis is the main mechanism of cisplatin-induced acute kidney injury. The role of microRNAs (miRNAs) in the apoptosis of renal tubular epithelial cells has... cupon ortowebWebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in … cup o noodle nutrition factsWebJul 1, 1999 · The results thus far suggest that CP70 and C30 cells initiate apoptosis via a caspase-3-dependent pathway. However, even in the absence of caspase-3 activation, A2780 cells do exhibit some morphological characteristics of cisplatin-induced apoptosis, including a subset of the biochemical features of PCD. easycity by dash livingWebFeb 18, 2024 · Collectively, miR-483-5p is upregulated by cisplatin and exacerbates cisplatin-induced AKI via negative regulation of GPX3 and contributing oxidative stress … easy cities to drawWebOct 5, 2014 · Cisplatin-Induced Cell Apoptosis Apoptosis is a controlled type of cell death which is energy-dependent leading to cell shrinkage, chromatin condensation, … cup o noodles breakfastWebApr 11, 2024 · Cisplatin induced DNA damage activates JNK and p73 and promotes their complex formation and leads to apoptosis. Cisplatin induces stabilization of p18 (Hamlet), a protein regulated by p38 MAPK. This enhances the ability of p53 to interact with and activate pro-apoptotic genes, PUMA and NOXA Full size image cupon office max